Cell surface cathepsin G can be used as an additional marker to distinguish T cell subsets

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dc.contributor.authorPenczek, Adriane
dc.contributor.authorBurster, Timo
dc.date.accessioned2019-12-18T05:42:51Z
dc.date.available2019-12-18T05:42:51Z
dc.date.issued2019-04
dc.description.abstractThe serine protease cathepsin G (CatG) is involved in numerous processes associated with the innate and adaptive immune system. During an immune response, neutrophils secrete CatG, which can bind to the cell surface of immune cells to provoke the proteolytic processing of cytokines and chemokines in order to stimulate lymphocytes. The present study analyzed peripheral blood mononuclear cells to characterize T cell populations in terms of their CatG content by flow cytometry. It was identified that CatG was exclusively present on the cell surface of a subset of T regulatory cells (Tregs), cluster of differentiation (CD) 39(+) Tregs, which expressed CatG in contrast to CD39(-) Tregs. Additionally, CatG was expressed on double positive CD4(+)CD8(+) T cells, T helper (Th) 9 cells and Th22 cells, implicating CatG as a novel marker to distinguish certain T cell subsets.en_US
dc.identifier.citationPenczek, A., & Burster, T. (2019). Cell surface cathepsin G can be used as an additional marker to distinguish T cell subsets. Biomedical reports, 10(4), 245-249.en_US
dc.identifier.urihttps://doi.org/10.3892/br.2019.1198
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/4463
dc.language.isoenen_US
dc.publisherSPANDIDOSen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.titleCell surface cathepsin G can be used as an additional marker to distinguish T cell subsetsen_US
dc.typeArticleen_US
workflow.import.sourcescience

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