SOLUBLE TAM RECEPTORS ARE POTENTIAL REGULATORS OF BLADDER CANCER PROGRESSION
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Date
2024
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Nazarbayev University School of Medicine
Abstract
Bladder cancer cells such as RT112 and T24 cells contain TAM receptors called Axl, Tyro3 and
Mer. These TAM receptors are cleaved and form soluble forms that can have impacts on signaling
pathways. The hypothesis of this dissertation is that soluble TAMs initiate downstream signals that
can be correlated with progression of bladder cancer. Therefore, RT112 and T24 bladder cancer cell
lines were analyzed using cell culture, western blotting, and wound healing assay. These cells
illustrate morphological changes and increased migration after addition of recombinant - TAM
receptors. Moreover, the soluble TAM receptors are found in RT112 and T24 that are biologically
active.
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Keywords
Type of access: Gated, TAM receptors, soluble TAM receptors, Axl, Tyro3, Mer, bladder cancer
Citation
Kuantayeva, A. (2024). Soluble TAM receptors are potential regulators of bladder cancer progression. Nazarbayev University School of Medicine.