ROLE OF PERIOSTIN IN RHEUMATOID ARTHRITIS

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dc.contributor.authorKurmanova, Asiya
dc.date.accessioned2024-06-25T07:11:34Z
dc.date.available2024-06-25T07:11:34Z
dc.date.issued2024-04-26
dc.description.abstractRheumatoid Arthritis (RA) is defined as an autoimmune disease of chronic character that principally leads to inflammation in synovial joints. Periostin belongs to the extracellular matrix protein family. It plays a role in ontogenesis and is produced in adult tissues subjected to mechanical forces inclusive of bones and joints. It has been shown to have increased expression in the synovium of patients with RA (Kasperovitz et al., 2005). In research by Chijimatsu et al. (2015), human primary chondrocytes expressed interleukin (IL)-6, IL-8, IL-1, matrix metalloproteinase (MMP)-1, MMP-3, MMP-13, as well as nitric oxide synthase-2 (NOS2) in response to periostin. This suggests that periostin may amplify inflammatory events. Per contra, in the results demonstrated by Cheon (2017), mean histologic severity scores were elevated in periostin-deficient mice compared to wild type implying a protective role of periostin in RA. Considering the contradictory results of the abovementioned studies and the lack of information regarding the presence of periostin splice variants, further investigations are needed. This project examines periostin's anti-inflammatory role in a mouse RA model. In this study, 4 wild type and 2 periostin-KO underwent immunization injections to establish a collagen-induced arthritis (CIA) mouse model (Brand et al., 2007). The effect was evaluated observationally, by taking weight and hind paw measurements, histologically and immunohistochemically by staining for periostin and RAR-related orphan receptor gamma (RORĪ³).en_US
dc.identifier.citationKurmanova, A. (2024). Role of Periostin in Rheumatoid Arthritis. Nazarbayev University School of Medicineen_US
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/7996
dc.language.isoenen_US
dc.publisherNazarbayev University School of Medicineen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.subjectRheumatoid Arthritisen_US
dc.subjectMouse Modelen_US
dc.subjectCIAen_US
dc.subjectPeriostinen_US
dc.subjectC57BL/6en_US
dc.subjectRAR-related orphan receptor gammaen_US
dc.subjectRORĪ³en_US
dc.subjectTh17en_US
dc.subjectType of access: Embargoen_US
dc.titleROLE OF PERIOSTIN IN RHEUMATOID ARTHRITISen_US
dc.typeMaster's thesisen_US
workflow.import.sourcescience

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