Aberrant repair initiated by the adenine-DNA glycosylase does not play a role in UV-induced mutagenesis in Escherichia coli
| dc.contributor.author | Zutterling, Caroline | |
| dc.contributor.author | Mursalimov, Aibek | |
| dc.contributor.author | alhaoui, Ibtissam | |
| dc.contributor.author | Koshenov, Zhanat | |
| dc.contributor.author | Akishev, Zhiger | |
| dc.contributor.author | Bissenbaev, Amangeldy K. | |
| dc.contributor.author | Mazon, Gerard | |
| dc.contributor.author | Geacintov, Nicolas E. | |
| dc.contributor.author | Gasparutto, Didier | |
| dc.contributor.author | Groisman, Regina | |
| dc.contributor.author | Zharkov, Dmitry O. | |
| dc.contributor.author | Matkarimov, Bakhyt T. | |
| dc.contributor.author | Saparbaev, Murat | |
| dc.date.accessioned | 2020-03-31T10:32:38Z | |
| dc.date.available | 2020-03-31T10:32:38Z | |
| dc.date.issued | 2018-12-15 | |
| dc.description.abstract | DNA repair is essential to counteract damage to DNA induced by endo- and exogenous factors, to maintain genome stability. However, challenges to the faithful discrimination between damaged and non-damaged DNA strands do exist, such as mismatched pairs between two regular bases resulting from spontaneous deamination of 5-methylcytosine or DNA polymerase errors during replication. To counteract these mutagenic threats to genome stability, cells evolved the mismatch-specific DNA glycosylases that can recognize and remove regular DNA bases in the mismatched DNA duplexes. The Escherichia coli adenine-DNA glycosylase (MutY/MicA) protects cells against oxidative stress-induced mutagenesis by removing adenine which is mispaired with 7,8-dihydro-8-oxoguanine (8oxoG) in the base excision repair pathway.... | en_US |
| dc.identifier.citation | Zutterling C, Mursalimov A, Talhaoui I, Koshenov Z, Akishev Z, Bissenbaev AK, Mazon G, Geacintov NE, Gasparutto D, Groisman R, Zharkov DO, Matkarimov BT, Saparbaev M. 2018. Aberrant repair initiated by the adenine-DNA glycosylase does not play a role in UV-induced mutagenesis in Escherichia coli. PeerJ 6:e6029 https://doi.org/10.7717/peerj.6029 | en_US |
| dc.identifier.uri | http://nur.nu.edu.kz/handle/123456789/4576 | |
| dc.language.iso | en | en_US |
| dc.publisher | BIOCHEMISTRY, BIOPHYSICS AND MOLECULAR BIOLOGY | en_US |
| dc.rights | Attribution-NonCommercial-ShareAlike 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/us/ | * |
| dc.subject | Nucleotide excision repair | en_US |
| dc.title | Aberrant repair initiated by the adenine-DNA glycosylase does not play a role in UV-induced mutagenesis in Escherichia coli | en_US |
| dc.type | Article | en_US |
| workflow.import.source | science |