DEVELOPING A MODEL FOR AGE-RELATED DEMENTIA THROUGH THE ADMINISTRATION OF D-GALACTOSE AND ALUMINUM CHLORIDE

Abstract

Dementia is disease that patient suffers from cognitive disease that is severe enough to interfere with daily life. There are several animal models of dementia, one of them is chemically induced animal model which will be studied in this paper. The chemicals are AlCl3 and D-galactose. Aluminum is known for its neurotoxic properties, promoting aggregation of amyloid-beta and tau proteins. It interferes with various cellular functions, enhancing oxidative stress and inflammation. D-galactose generates reactive oxygen species (ROS), leading to oxidative damage to neurons. 20 Female Balb/c mice divided into 2 groups: experimental and control. Experimental mice received subcutaneously 200 mg/kg of D-galactose and intraperitonially 400 mg/kg of Aluminum chloride once per day for 90 days. Control mice received subcutaneously 200 uLof PBS and intraperitonially 200 uLsaline water. Cognitive abilities were assessed using open field, marble, conditioned taste aversion, novel cage tests. To conclude, it is found that there is no significant difference in weight, behavior, and cognitive functions between mice who were administered with AlCl3 (400mg/kg) and D-galactose (200mg/kg) and control mice.