Altered NR2A/NR2B ratio in hippocampus of spatial learning-impaired aged rats
Loading...
Date
2014
Authors
Tokay, T.
Rehberg, M.
Kirschstein, T.
Rohde, M.
Mueller, L.
Askarova, Sholpan
Kohling, R.
Zhumadilov, Z.
Journal Title
Journal ISSN
Volume Title
Publisher
Nazarbayev University
Abstract
The activation of the N-methyl-D-aspartate receptor (NMDAR) is critical for the
induction of synaptic plasticity in the hippocampus. Aging can alter glutamatergic synaptic transmission
in the hippocampus, and cognitive impairments in aged animals are accompanied by reduced NMDARmediated
plasticity at Schaffer collateral—CA1 synapses. However, the specific contribution of NMDAR
subunits to NMDAR-mediated synaptic responses in aged tissue has not yet been fully understood. The
main purpose of present study was to examine whether there is an impact of aging on NMDAR subunit
expression and whether synaptic plasticity may depend on NMDAR subunit composition in the aged
hippocampus.
Description
Keywords
hippocampus, aged animals, NR2B/NR2A ratio, synaptic plasticity