Novel Small Molecule Inhibitors of Cancer Stem Cell Signaling Pathways

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dc.contributor.authorAbetov, Danysh
dc.contributor.authorMustapova, Zhanar
dc.contributor.authorSaliev, Timur
dc.contributor.authorBulanin, Denis
dc.contributor.authorBatyrbekov, Kanat
dc.contributor.authorGilman, Charles P.
dc.date.accessioned2017-01-12T09:49:37Z
dc.date.available2017-01-12T09:49:37Z
dc.date.issued2015-12-01
dc.description.abstractThe main aim of oncologists worldwide is to understand and then intervene in the primary tumor initiation and propagation mechanisms. This is essential to allow targeted elimination of cancer cells without altering normal mitotic cells. Currently, there are two main rival theories describing the process of tumorigenesis. According to the Stochastic Model, potentially any cell, once defunct, is capable of initiating carcinogenesis. Alternatively the Cancer Stem Cell (CSC) Model posits that only a small fraction of undifferentiated tumor cells are capable of triggering carcinogenesis. Like healthy stem cells, CSCs are also characterized by a capacity for self-renewal and the ability to generate differentiated progeny, possibly mediating treatment resistance, thus leading to tumor recurrence and metastasis. Moreover, molecular signaling profiles are similar between CSCs and normal stem cells, including Wnt, Notch and Hedgehog pathways. Therefore, development of novel chemotherapeutic agents and proteins (e.g., enzymes and antibodies) specifically targeting CSCs are attractive pharmaceutical candidates. This article describes small molecule inhibitors of stem cell pathways Wnt, Notch and Hedgehog, and their recent chemotherapy clinical trials.ru_RU
dc.identifier.citationAbetov, D., Mustapova, Z., Saliev, T., Bulanin, D., Batyrbekov, K., & Gilman, C. P. (2015). Novel Small Molecule Inhibitors of Cancer Stem Cell Signaling Pathways. Stem Cell Reviews and Reports, 11(6), 909-918. DOI: 10.1007/s12015-015-9612-xru_RU
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/2256
dc.language.isoenru_RU
dc.publisherStem Cell Reviews and Reportsru_RU
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectcancerru_RU
dc.subjecthedgehogru_RU
dc.subjectinhibitorru_RU
dc.subjectnotchru_RU
dc.subjectsignaling pathwayru_RU
dc.subjectstem cellsru_RU
dc.subjectwntru_RU
dc.titleNovel Small Molecule Inhibitors of Cancer Stem Cell Signaling Pathwaysru_RU
dc.typeArticleru_RU

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