IL-10-1082 A/G pomoter polimorphism is associated with copd
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Date
2016-05
Authors
Imanbay, A.
Turbekova, Sh.
Akparova, A.Yu.
Abishev, M.T.
Bersimbaev, R. I.
Journal Title
Journal ISSN
Volume Title
Publisher
National Laboratory Astana, NAZARBAYEV UNIVERSITY
Abstract
Interleukin-10 is an important immunoregulatory cytokine produced by many
cell populations. It inhibits the production of proinflammatory cytokines by macrophages and
thus has immunosuppressive effects on T cells, monocytes and macrophages. IL-10 has a
protective effect against airway hyperresponsiveness and inflammation. It is a candidate gene
in the pathophysiological mechanisms of inflammatory and autoimmune diseases. According to
research, the most important functional polymorphism is the replacement of A —> G in position
-1082 (rs 1800896). This SNP localized in the binding site of the transcription factor, resulting in
a change in IL-10 production and secretion.
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow
obstruction associated with chronic lung inflammatory process, which is caused by action of
pathogenic particles and gases. Many of inflammatory cells, enzymes and mediators, that
enhance the pathological changes and cause structural alteration, are involved in the formation
of the inflammatory process.
The aim of our study was to determine the distribution of polymorphic gene variants IL10 in
COPD patients.
Description
Keywords
chronic obstructive pulmonary disease, gene polymorphism, interleukin-10
Citation
A. Imanbay, Sh. Turbekova, A.Yu. Akparova, M.T. Abishev, and R. I. Bersimbaev. 2016. IL-10-1082 A/G pomoter polimorphism is associated with copd. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University.