EDITORIAL: CELLULAR AND MOLECULAR MECHANISMS AT THE PROLIFERATION STAGE IN WOUND HEALING: FROM SCARRING TO TISSUE REGENERATION

Abstract

Wound healing is a complex physiological reaction in our body to tissue injury that can lead to the impairment of the original organ functions depending on the area of tissue injury. Many cell types participate in the wound healing process, including but not limited to, tissue resident cells, cells of the immune system, vascular cells, fibroblasts, and tissue progenitor/stem cells. However, the cellular and molecular regulatory mechanisms of wound healing are not yet fully identified. In the proliferation stage, granulation tissues develop accompanied by matrix deposition and neovascularization, which lead to proper regenerative responses including epithelialization.