GENE POLYMORPHISM AND TOTAL GENETIC SCORE IN MARTIAL ARTS ATHLETES WITH DIFFERENT ATHLETIC QUALIFICATIONS
Loading...
Date
2022
Authors
Vostrikova, Anna
Pechenkina, Victoria
Danilova, Maria
Boronnikova, Svetlana
Kalendar, Ruslan
Journal Title
Journal ISSN
Volume Title
Publisher
Genes
Abstract
The personalized approach in sports genetics implies considering the allelic variants
of genes in polymorphic loci when adjusting the training process of athletes. The personalized
approach is used both in sports genetics and in medicine to identify the influence of genotype
on the manifestations of human physical qualities that allow to achieve high sports results or to
assess the impact of genotype on the development and course of diseases. The impact of genes of
the renin-angiotensin and kinin-bradykinin systems in the development of cardiovascular disease
in athletes has not been defined. This study aims to determine the polymorphisms of four genes
(ACE, BDKRB2, PPARGC1A and NOS3) and the total genetic score to reveal the predisposition to the
formation of physical qualities in martial arts athletes with different athletic abilities. The products of
these four genes are involved in the control of blood pressure. The allelic variants of these genes are
associated with the development of the physical quality “endurance” and have an indirect influence
on the formation of speed and power qualities. The total genetic score (TGS: from 0 to 100 arbitrary
units) was calculated from the genotype score in each polymorphism. The athletes were divided
into Group I with high and Group II with low qualifications depending on their sports success.
Single nucleotide polymorphisms (SNPs) are identified through restriction endonucleases cleavage
for PCR amplicons for discriminating between alleles of the target genes ACE (rs4646994), BDKRB2
(rs5810761), PPARGC1A (rs8192673) and NOS3 (rs1799983). Significant differences between the allelic
variants of target genes and athletic ability were found between Group I and Group II for genotype
G/G of NOS3 gene and genotypes Gly/Gly and Gly/Ser of PPARGC1A gene. The data obtained
confirm that athletes with unfavourable genotypes are excluded in the screening phase because their
endurance is not fully developed to the required level in martial arts. Martial arts athletes with the
highest TGS have the highest skill level. Polymorphic loci of four genes whose products are involved
in blood pressure control (ACE, BDKRB2, NOS3 and PPARGC1A) can be used in martial arts not only
to determine predisposition to cardiovascular disease but also to predispose to the development of
speed and power qualities and endurance. The total genetic score can serve as a tool for predicting
athletic success
Description
Keywords
Type of access: Open Access, the renin-angiotensin and the kallikrein-kinin systems, endurance, athletes, sports qualification, total genetic score
Citation
Vostrikova, A. M., Pechenkina, V. F., Danilova, M. M., Boronnikova, S. V., & Kalendar, R. (2022). Gene Polymorphism and Total Genetic Score in Martial Arts Athletes with Different Athletic Qualifications. Genes, 13(9), 1677. https://doi.org/10.3390/genes13091677