Genetic risk factors for restenosis after percutaneous coronary intervention in Kazakh population

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dc.contributor.authorZholdybayeva, Elena V.
dc.contributor.authorTalzhanov, Yerkebulan A.
dc.contributor.authorAitkulova, Akbota M.
dc.contributor.authorTarlykov, Pavel V.
dc.contributor.authorKulmambetova, Gulmira N.
dc.contributor.authorIskakova, Aisha N.
dc.contributor.authorDzholdasbekova, Aliya U.
dc.contributor.authorVisternichan, Olga A.
dc.contributor.authorTaizhanova, Dana Zh.
dc.contributor.authorRamanculov, Yerlan M.
dc.date.accessioned2017-11-16T09:20:03Z
dc.date.available2017-11-16T09:20:03Z
dc.date.issued2016
dc.description.abstractBackground: After coronary stenting, the risk of developing restenosis is from 20 to 35 %. The aim of the present study is to investigate the association of genetic variation in candidate genes in patients diagnosed with restenosis in the Kazakh population. Methods: Four hundred fifty-nine patients were recruited to the study; 91 patients were also diagnosed with diabetes and were excluded from the sampling. DNA was extracted with the salting-out method. The patients were genotyped for 53 single-nucleotide polymorphisms. Genotyping was performed on the QuantStudio 12K Flex (Life Technologies). Differences in distribution of BMI score among different genotype groups were compared by analysis of variance (ANOVA). Also, statistical analysis was performed using R and PLINK v.1.07. Haplotype frequencies and LD measures were estimated by using the software Haploview 4.2. Results: A logistic regression analysis found a significant difference in restenosis rates for different genotypes. FGB (rs1800790) is significantly associated with restenosis after stenting (OR = 2.924, P = 2.3E−06, additive model) in the Kazakh population. CD14 (rs2569190) showed a significant association in the additive (OR = 0.08033, P = 2.11E−09) and dominant models (OR = 0.05359, P = 4.15E−11). NOS3 (rs1799983) was also highly associated with development of restenosis after stenting in additive (OR = 20.05, P = 2.74 E−12) and recessive models (OR = 22.24, P = 6.811E−10). Conclusions: Our results indicate that FGB (rs1800790), CD14 (rs2569190), and NOS3 (rs1799983) SNPs could be genetic markers for development of restenosis in Kazakh population. Adjustment for potential confounder factor BMI gave almost the same results.ru_RU
dc.identifier.citationZholdybayeva Elena V. et al.(>9), 2016, Genetic risk factors for restenosis after percutaneous coronary intervention in Kazakh population, Human Genomicsru_RU
dc.identifier.uriDOI 10.1186/s40246-016-0077-z
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/2825
dc.language.isoenru_RU
dc.publisherHuman Genomicsru_RU
dc.rightsOpen Access - the content is available to the general publicru_RU
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectcoronary heart diseaseru_RU
dc.subjectrestenosisru_RU
dc.subjectSNPru_RU
dc.subjectgenotypingru_RU
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Biologyru_RU
dc.titleGenetic risk factors for restenosis after percutaneous coronary intervention in Kazakh populationru_RU
dc.typeArticleru_RU

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