Molecular mimicry of brucella melitensis epitopes in mouse and human arthritis
Loading...
Date
2014
Authors
Bexeitov, Y. K.
Ramez, M
Forde, T. S.
Adarichev, V. A.
Journal Title
Journal ISSN
Volume Title
Publisher
Nazarbayev University
Abstract
Brucellosis is one of the most frequent zoonosis worldwide. Infection is transferable
to humans, where brucellosis is associated with high incidence of osteoarticular disease including
osteomyelitis, arthritis and spondyloarthritis. Peripheral arthritis and sacroiliitis often develop in patients
with no or low count of live Brucella. Recently, we demonstrated that mice develop spontaneous arthritis
several weeks after acute infection when bacteria are already eradicated. We aim to decipher immune
mechanism of the brucellosis-associated delayed arthritis that has not been elucidated so far.
Description
Keywords
brucellosis, osteomyelitis, arthritis, spondyloarthritis, cytotoxic T cells