Detection of Paracetamol in Water and Urea in Artificial Urine with Gold Nanoparticle@Al Foil Cost-efficient SERS Substrate

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dc.contributor.authorMukanova, Zhansaya
dc.contributor.authorGudun, Kristina
dc.contributor.authorElemessova, Zarina
dc.contributor.authorKhamkhash, Laura
dc.contributor.authorRalchenko, Ekaterina
dc.contributor.authorBukasov, Rostislav
dc.date.accessioned2020-03-27T05:35:30Z
dc.date.available2020-03-27T05:35:30Z
dc.date.issued2018
dc.descriptionhttps://www.jstage.jst.go.jp/article/analsci/34/2/34_183/_articleen_US
dc.description.abstractWe demonstrated that a cost-efficient, easy to prepare, hybrid SERS substrate-gold nanoparticles (AuNPs) on untreated Al foil (AlF) can effectively detect pharmaceuticals, such as paracetamol and clinical biomarkers, like urea in artificial urine. The limit of detection (LOD) for paracetamol on AuNPs on AlF is superior (0.1 vs. 1 mM ) to the LOD reported for SERS detection of paracetamol in the literature. For SERS detection of urea in urine, AuNPs on both Al foil and Au film performed much better than AuNPs on glass, in terms of the concentration range, linearity and LOD. However, assay on AuNPs on AlF showed a better semi-logarithmic trendline with R2 = 0.98 than an assay on AuNPs on Au film with R2 = 0.94. They have comparable sensitivity with LOD 0.024 and 0.017 M, respectively. The limit of quantification (LOQ) of the former is 0.026 M, which makes it sufficient for the quantification of urea in urine at both normal and pathophysiological (0.03 – 0.15 M) concentration.en_US
dc.identifier.citationMUKANOVA, Z., GUDUN, K., ELEMESSOVA, Z., KHAMKHASH, L., RALCHENKO, E., & BUKASOV, R. (2018). Detection of Paracetamol in Water and Urea in Artificial Urine with Gold Nanoparticle@Al Foil Cost-efficient SERS Substrate. Analytical Sciences, 34(2), 183–187. https://doi.org/10.2116/analsci.34.183en_US
dc.identifier.issn0910-6340
dc.identifier.other1348-2246
dc.identifier.other10.2116/analsci.34.183
dc.identifier.urihttps://www.jstage.jst.go.jp/article/analsci/34/2/34_183/_pdf/-char/en
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/4552
dc.language.isoenen_US
dc.publisherNihon Bunseki Kagakkaien_US
dc.relation.ispartofseriesAnalytical Sciences;Volume 34 (2018) Issue 2
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistryen_US
dc.subjectparacetamolen_US
dc.subjectdetectionen_US
dc.subjectgold nanoparticleen_US
dc.subjectSurface enhanced Raman spectroscopyen_US
dc.subjectSERSen_US
dc.subjectAl foilen_US
dc.titleDetection of Paracetamol in Water and Urea in Artificial Urine with Gold Nanoparticle@Al Foil Cost-efficient SERS Substrateen_US
dc.typeArticleen_US
workflow.import.sourcescience

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