ELM––the eukaryotic linear motif resource in 2020
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Date
2020-01-08
Authors
Bukirova, Dayana
Kumar, Manjeet
Gouw, Marc
Michael, Sushama
Samano-Sanchez, Hugo
Pancsa, Rita
Glavina, Juliana
Diakogianni, Athina
Valverde, Jesus Alvarado
Calyseva, Jelena
Journal Title
Journal ISSN
Volume Title
Publisher
Oxford University Press
Abstract
The eukaryotic linear motif (ELM) resource is a repository of manually curated experimentally validated short linear motifs (SLiMs). Since the initial release almost 20 years ago, ELM has become an indispensable resource for the molecular biology community for investigating functional regions in many proteins. In this update, we have added 21 novel motif classes, made major revisions to 12 motif classes and added >400 new instances mostly focused on DNA damage, the cytoskeleton, SH2-binding phosphotyrosine motifs and motif mimicry by pathogenic bacterial effector proteins. The current release of the ELM database contains 289 motif classes and 3523 individual protein motif instances manually curated from 3467 scientific publications. ELM is available at: http://elm.eu.org.
Description
Keywords
Research Subject Categories::NATURAL SCIENCES::Biology::Cell and molecular biology
Citation
Kumar, M., Gouw, M., Michael, S., Sámano-Sánchez, H., Pancsa, R., Glavina, J., ... & Palopoli, N. (2020). ELM—the eukaryotic linear motif resource in 2020. Nucleic acids research, 48(D1), D296-D306.