Identifying risk factors associated with smear positivity of pulmonary tuberculosis in Kazakhstan

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dc.contributor.authorHermosilla, Sabrina
dc.contributor.authorYou, Paul
dc.contributor.authorAifah, Angela
dc.contributor.authorAbildayev, Tleukhan
dc.contributor.authorAkilzhanova, Ainur
dc.contributor.authorKozhamkulov, Ulan
dc.contributor.authorMuminov, Talgat
dc.contributor.authorDarisheva, Meruert
dc.contributor.authorZhussupov, Baurzhan
dc.contributor.authorTerlikbayeva, Assel
dc.contributor.authorEl-Bassel, Nabila
dc.contributor.authorSchluger, Neil
dc.date.accessioned2017-11-13T04:34:05Z
dc.date.available2017-11-13T04:34:05Z
dc.date.issued2017-03-01
dc.description.abstractBackground Sputum smear-positive tuberculosis (TB) patients have a high risk of transmission and are of great epidemiological and infection control significance. Little is known about the smearpositive populations in high TB burden regions, such as Kazakhstan. The objective of this study is to characterize the smear-positive population in Kazakhstan and identify associated modifiable risk factors. Methods Data on incident TB cases' (identified between April 2012 and March 2014) socio-demographic, risk behavior, and comorbidity characteristics were collected in four regions of Kazakhstan through structured survey and medical record review. We used multivariable logistic regression to determine factors associated with smear positivity. Results Of the total sample, 193 (34.3%) of the 562 study participants tested smear-positive. In the final adjusted multivariable logistic regression model, sex (adjusted odds ratio (aOR) = 2.0, 95% CI:1.3±3.1, p < 0.01), incarceration (aOR = 3.6, 95% CI:1.2±11.1, p = 0.03), alcohol dependence (aOR = 2.6, 95% CI:1.2±5.7, p = 0.02), diabetes (aOR = 5.0, 95% CI:2.4±10.7, p < 0.01), and physician access (aOR = 2.7, 95% CI:1.3±5.5p < 0.01) were associated with smear-positivity. Conclusions Incarceration, alcohol dependence, diabetes, and physician access are associated with smear positivity among incident TB cases in Kazakhstan. To stem the TB epidemic, screening, treatment and prevention policies should address these factors.ru_RU
dc.identifier.citationHermosilla Sabrina et al.(>11), 2017(March 1), Identifying risk factors associated with smear positivity of pulmonary tuberculosis in Kazakhstan, PLoS ONE,ru_RU
dc.identifier.uridoi:10.1371/journal. pone.0172942
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/2780
dc.language.isoenru_RU
dc.publisherPLoS ONEru_RU
dc.rightsOpen Access - the content is available to the general publicru_RU
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectpulmonary tuberculosisru_RU
dc.subjectsputum smear-positive tuberculosisru_RU
dc.subjectKazakhstanru_RU
dc.titleIdentifying risk factors associated with smear positivity of pulmonary tuberculosis in Kazakhstanru_RU
dc.typeArticleru_RU

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