Role of astrocyte aging in the pathogenesis of alzheimer`s disease
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Date
2016-05
Authors
Imangali, N.
Alimbetov, D.
Tsoy, A.
Saparbayev, S.
Askarova, Sh.
Journal Title
Journal ISSN
Volume Title
Publisher
National Laboratory Astana, NAZARBAYEV UNIVERSITY
Abstract
Alzheimer's disease (AD) is the most abundant severe and irreversible
neurodegenerative disease in the world that affects people over 65 years old. The major
hallmarks of AD pathology are the senile p-amyloid plaques, hyperphosphorylated neurofibrillary
tangles, accompanied by severe neuroinflammation, synaptic disruption, neuronal degeneration
and apoptosis, eventually triggering cerebral atrophy, memory loss and cognitive decline. The
deposition and increase of p-amyloid levels in the brain induce the cascade of signals triggering
production of neurotoxic molecules such as reactive oxygen species, nitric oxide, and proinflammatory
cytokines and chemokines that cause neuroinflammation and neurodegeneration
eventually resulting into dementia. Aging is the key risk factor for many inflammatory diseases
including AD. However, the correlation of aging and AD is poorly investigated. Especially, the
cytotoxic effects of p-amyloid in aging glial cells have been poorly explored. Human astrocytes
are the most abundant CNS cells that undergo senescence with age and in response to stress.
Therefore, it is hypothesized that sensitivity to p-amyloid may significantly change during in vitro
senescence of astrocytes. The aim of this study is to investigate the mechanisms of cytotoxic
actions of p-amyloid peptide in senescent astrocytes.
Description
Keywords
Alzheimer's disease
Citation
Imangali N., Alimbetov D., Tsoy A., Saparbayev S., and Askarova Sh. 2016. Role of astrocyte aging in the pathogenesis of alzheimer`s disease. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1554