PI4,5P2 regulates the polarized trafficking of integrins through EXO70 for directional cell migration

Abstract

The polarized delivery of integrin adhesion molecules to the leading edge is required for cell migration and has been linked to cancer cell invasion, cancer aggressiveness, and poor patient outcome (1,2). Thus, regulators of integrin traffic may represent new molecular targets to inhibit tumor progression. However, identifying the regulatory networks that control integrin traffic has posed a big challenge, because, in contrast to the internalization of other cargoes, integrins take diverse routes, depending on their specific ligand, activation state, type of adhesion structure and cell type assayed.