Placental Failure in Mice Lacking the Mammalian Homolog of Glial Cells Missing, GCMa

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dc.contributor.authorRiethmacher-Sonnenberg, Eva
dc.date.accessioned2016-03-30T03:36:52Z
dc.date.available2016-03-30T03:36:52Z
dc.date.issued2000
dc.description.abstractThe GCM family of transcription factors consists of Drosophila melanogaster GCM, an important regulator of gliogenesis in the fly, and its two mammalian homologs, GCMa and GCMb. To clarify the function of these mammalian homologs, we deleted GCMa in mice. Genetic ablation of murine GCMa (mGCMa) is embryonic lethal, with mice dying between 9.5 and 10 days postcoitum. At the time of death, no abnormalities were apparent in the embryo proper. Nervous system development, in particular, was not impaired, as might have been expected in analogy to Drosophila GCM. Instead, placental failure was the cause of death. In agreement with the selective expression of mGCMa in labyrinthine trophoblasts, mutant placentas did not develop a functional labyrinth layer, which is necessary for nutrient and gas exchange between maternal and fetal blood. Only a few fetal blood vessels entered the placenta, and these failed to thrive and branch normally. Labyrinthine trophoblasts did not differentiate. All other layers of the placenta, including spongiotrophoblast and giant cell layer, formed normally. Our results indicate that mGCMa plays a critical role in trophoblast differentiation and the signal transduction processes required for normal vascularization of the placentaru_RU
dc.identifier.citationRiethmacher-Sonnenberg Eva; 2000; Placental Failure in Mice Lacking the Mammalian Homolog of Glial Cells Missing, GCMa; MOLECULAR AND CELLULAR BIOLOGYru_RU
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/1351
dc.language.isoenru_RU
dc.publisherAmerican Society for Microbiologyru_RU
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Biology::Organism biology::Microbiologyru_RU
dc.subjectDrosophila melanogaster GCMru_RU
dc.subjectGlial Cells Missingru_RU
dc.subjectMammalian Homologru_RU
dc.titlePlacental Failure in Mice Lacking the Mammalian Homolog of Glial Cells Missing, GCMaru_RU
dc.typeArticleru_RU

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