Characterization of biochemical properties of an apurinic/apyrimidinic endonuclease from Helicobacter pylori
| dc.contributor.author | Turgimbayeva, Aigerim | |
| dc.contributor.author | Abeldenov, Sailau | |
| dc.contributor.author | Zharkov, Dmitry O. | |
| dc.contributor.author | Ishchenko, Alexander A. | |
| dc.contributor.author | Ramankulov, Yerlan | |
| dc.contributor.author | Saparbaev, Murat | |
| dc.contributor.author | Khassenov, Bekbolat | |
| dc.date.accessioned | 2020-03-31T05:14:38Z | |
| dc.date.available | 2020-03-31T05:14:38Z | |
| dc.date.issued | 2018-08-15 | |
| dc.description.abstract | Apurinic/apyrimidinic (AP) endonucleases play critical roles in the repair of abasic sites and strand breaks in DNA. Complete genome sequences of Helicobacter pylori reveal that this bacterial specie has a single AP endonuclease. An H. pylori homolog of Xth (HpXth) is a member of exonuclease III family, which is represented by Escherichia coli Xth. Currently, it remains unknown whether this single AP endonuclease has DNA repair activities similar to those of its counterpart in E. coli and other bacteria. We report that HpXth possesses efficient AP site cleavage, 3’-repair phosphodiesterase, and 3’-phosphatase activities but not the nucleotide incision repair function... | en_US |
| dc.identifier.citation | Turgimbayeva A, Abeldenov S, Zharkov DO, Ishchenko AA, Ramankulov Y, Saparbaev M, et al. (2018) Characterization of biochemical properties of an apurinic/apyrimidinic endonuclease from Helicobacter pylori. PLoS ONE 13(8): e0202232. https://doi.org/10.1371/journal.pone.0202232 | en_US |
| dc.identifier.uri | http://nur.nu.edu.kz/handle/123456789/4565 | |
| dc.language.iso | en | en_US |
| dc.publisher | PLoS ONE | en_US |
| dc.rights | Attribution-NonCommercial-ShareAlike 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/us/ | * |
| dc.subject | Helicobacter pylori | en_US |
| dc.title | Characterization of biochemical properties of an apurinic/apyrimidinic endonuclease from Helicobacter pylori | en_US |
| dc.type | Article | en_US |
| workflow.import.source | science |