RETROSPECTIVE ANALYSIS OF MATERNAL, NEONATAL AND EARLY-LIFE RISK FACTORS IN CHILDREN WITH INFLAMMATORY BOWEL DISEASE.
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Date
2024
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Nazarbayev University School of Medicine
Abstract
Background: IBD is believed to arise from genetic, environmental and geological aspects.
Possibly related environmental factors extend from a child delivery mode and exposures in first
year such as breastfeeding, antibiotic administration to late adulthood exposures as smoking,
lifestyle, infections and diet.
Methods: We have recruited 50 patients in each group: cases and controls.Cases consisted of
children with IBD, while the control group included children who didn’t have a history of IBD or
any autoimmune disease. The data is analyzed by logistic regression. Risk factors that could
promote the IBD are the objective of this study.
Results: Logistic analysis revealed that risk of developing of IBD is significantly associated
height at birth (adjusted OR 1.79;95% CI:1.17 – 2.74,p<0.007), inversely associated with birth
week (adjusted OR 0.33;95% CI:0.2 – 0.56,p<0.001) and formula feeding (adjusted OR 0.1; 95%
CI:0.018 – 0.63, p=0.014).
Conclusion: Our study revealed that the odds of developing IBD increases by 79% with an
increase of height at birth by 1 cm, however the odds decrease by 69% as birth week increases
by 1 week. Children which were fed with formula have substantially lower odds of developing
IBD.
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Citation
Yegembayeva, N. (2024). Retrospective analysis of maternal, neonatal and early-life risk factors in children with inflammatory bowel disease. Nazarbayev University School of Medicine