PREDICTIVE VALUE OF BASAL SERUM PROGESTERONE FOR SUCCESSFUL IVF IN ENDOMETRIOSIS PATIENTS: THE NEED FOR A PERSONALIZED APPROACH

Simple item page
dc.contributor.authorBila, Jovan
dc.contributor.authorDotlic, Jelena
dc.contributor.authorSpremovic Radjenovic, Svetlana
dc.contributor.authorVidakovic, Snezana
dc.contributor.authorTulic, Lidija
dc.contributor.authorMicic, Jelena
dc.contributor.authorStojnic, Jelena
dc.contributor.authorBabovic, Ivana
dc.contributor.authorDmitrovic, Aleksandar
dc.contributor.authorChiantera, Vito
dc.contributor.authorLaganà, Antonio Simone
dc.contributor.authorTerzic, Milan
dc.date.accessioned2023-04-27T05:57:36Z
dc.date.available2023-04-27T05:57:36Z
dc.date.issued2022
dc.description.abstractThe data regarding the role of progesterone (P4) in reproductive events of endometriosis patients are limited. This prospective study aimed to examine the predictive value of basal P4 serum levels for successful in vitro fertilization (IVF) in patients with primary infertility and endometriosis. The study included 73 patients divided according to endometriosis treatment (surgery vs. control—no treatment). The general data, basal hormonal status, and pregnancy rates were determined for every patient. Clinical pregnancy was achieved in 40.3% of patients, and more often in patients treated for endometriosis before IVF. The regression analysis showed that higher basal P4 serum levels were associated with achieving pregnancy through IVF. When regression was adjusted for the patient and IVF characteristics, higher basal P4 serum levels were associated with pregnancy achievement in both groups of women, along with the basal serum levels of FSH, LH, and AMH; EFI score; and stimulation protocol. The ROC analysis showed that the basal P4 serum level for successful IVF should be 0.7ng/mL. The basal P4 serum level cut-off for IVF success in endometriosis patients was determined for the first time. Constructed models for IVF success prediction emphasize the importance of determining the basal P4 serum levels for the personalized treatment of endometriosisrelated infertility.en_US
dc.identifier.citationBila, J., Dotlic, J., Spremovic-Radjenovic, S., Vidakovic, S., Tulić, L., Micic, J., Stojnic, J., Babovic, I., Dmitrovic, A., Chiantera, V., Laganà, A. S., & Terzic, M. (2022). Predictive Value of Basal Serum Progesterone for Successful IVF in Endometriosis Patients: The Need for a Personalized Approach. Journal of Personalized Medicine, 12(10), 1639. https://doi.org/10.3390/jpm12101639en_US
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/7044
dc.language.isoenen_US
dc.publisherJournal of Personalized Medicineen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectType of access: Open Accessen_US
dc.subjectprogesteroneen_US
dc.subjectendometriosisen_US
dc.subjectsurgeryen_US
dc.subjectin vitro fertilizationen_US
dc.subjectpersonalized approachen_US
dc.titlePREDICTIVE VALUE OF BASAL SERUM PROGESTERONE FOR SUCCESSFUL IVF IN ENDOMETRIOSIS PATIENTS: THE NEED FOR A PERSONALIZED APPROACHen_US
dc.typeArticleen_US
workflow.import.sourcescience

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
jpm-12-01639.pdf
Size:
284.42 KB
Format:
Adobe Portable Document Format
Description:
article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
6.28 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Articles