Prepare for the Future: Dissecting the Spike to Seek Broadly Neutralizing Antibodies and Universal Vaccine for Pandemic Coronaviruses

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dc.contributor.authorL. Vangelista
dc.contributor.authorM. Secchi
dc.date.accessioned2025-08-20T04:04:30Z
dc.date.available2025-08-20T04:04:30Z
dc.date.issued2020-01-01
dc.description.abstractThis perspective examines opportunities for preparing against future coronavirus pandemics by dissecting conserved spike protein regions of SARS‑CoV‑2, SARS‑CoV, and MERS‑CoV. The authors argue that targeting conserved, autonomously folding spike subdomains could enable elicitation of broadly neutralizing antibodies (bnAbs) and guide the development of a universal coronavirus vaccine. They highlight potential risks posed by antibody‑dependent enhancement (ADE) when targeting variable domains like the RBD and suggest focusing instead on more conserved spike epitopes for broader immunization strategies., en
dc.identifier.citationVangelista, L.; Secchi, M. (2020). Front. Mol. Biosci., 7:226. https://doi.org/10.3389/fmolb.2020.00226en
dc.identifier.doi10.3389/fmolb.2020.00226
dc.identifier.urihttps://doi.org/10.3389/fmolb.2020.00226
dc.identifier.urihttps://nur.nu.edu.kz/handle/123456789/9653
dc.language.isoen
dc.publisherFrontiers
dc.relation.ispartofFrontiers in Molecular Biosciencesen
dc.rightsOpen accessen
dc.sourceFrontiers in Molecular Biosciences, 7, 226, (2020)en
dc.subjectbroadly neutralizing Absen
dc.subjectuniversal vaccineen
dc.subjectspike proteinen
dc.titlePrepare for the Future: Dissecting the Spike to Seek Broadly Neutralizing Antibodies and Universal Vaccine for Pandemic Coronavirusesen
dc.typeJournal Articleen

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