ROLE OF BASE EXCISION REPAIR PATHWAY IN THE PROCESSING OF COMPLEX DNA DAMAGE GENERATED BY OXIDATIVE STRESS AND ANTICANCER DRUGS
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Date
2021-01-22
Authors
Baiken, Yeldar
Kanayeva, Damira
Taipakova, Sabira
Groisman, Regina
Ishchenko, Alexander A.
Begimbetova, Dinara
Matkarimov, Bakhyt
Saparbaev, Murat
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers in Cell and Developmental Biology
Abstract
Chemical alterations in DNA induced by genotoxic factors can have a complex nature
such as bulky DNA adducts, interstrand DNA cross-links (ICLs), and clustered DNA
lesions (including double-strand breaks, DSB). Complex DNA damage (CDD) has a
complex character/structure as compared to singular lesions like randomly distributed
abasic sites, deaminated, alkylated, and oxidized DNA bases. CDD is thought to be
critical since they are more challenging to repair than singular lesions. Although CDD
naturally constitutes a relatively minor fraction of the overall DNA damage induced
by free radicals, DNA cross-linking agents, and ionizing radiation, if left unrepaired,
these lesions cause a number of serious consequences, such as gross chromosomal
rearrangements and genome instability. If not tightly controlled, the repair of ICLs
and clustered bi-stranded oxidized bases via DNA excision repair will either inhibit
initial steps of repair or produce persistent chromosomal breaks and consequently be
lethal for the cells....
Description
Keywords
inter-strand DNA crosslink, bulky DNA adduct, base excision repair, DNA glycosylase, nucleotide excision repair
Citation
Baiken Y, Kanayeva D, Taipakova S, Groisman R, Ishchenko AA, Begimbetova D, Matkarimov B and Saparbaev M (2021) Role of Base Excision Repair Pathway in the Processing of Complex DNA Damage Generated by Oxidative Stress and Anticancer Drugs. Front. Cell Dev. Biol. 8:617884. doi: 10.3389/fcell.2020.617884