GENETIC VARIATIONS INFLUENCING GLUCOSE HOMEOSTASIS AND INSULIN SECRETION AND THEIR ASSOCIATIONS WITH AUTISM SPECTRUM DISORDER IN KAZAKHSTAN

Abstract

There is a complex interaction between glucose and insulin homeostasis pathways, diabetes and autism spectrum disorder (ASD). It is known that neuronal migration pathways may be interrupted by intrauterine hyperinsulinemia and hyperglycemia. Moreover, neonatal hypoglycemia which is related to mitochondrial dysfunction has a potential role that influences ASD pathogenesis [6,7]. We present here a preliminary case-control study on children and adolescents (8 – 15 years old) with and without autism spectrum disorder examining the association between genetic polymorphisms impacting glucose and insulin homeostasis and autism spectrum disorder in Kazakhstan...