Cancer-related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubes

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dc.contributor.authorDmitriev, Petr
dc.contributor.authorKairov, Ulykbek
dc.contributor.authorRobert, Thomas
dc.contributor.authorBarat, Ana
dc.contributor.authorLazar, Vladimir
dc.contributor.authorCarnac, Gilles
dc.contributor.authorLaoudj-Chenivesse, Dalila
dc.contributor.authorVassetzky, Yegor S.
dc.date.accessioned2017-11-09T05:12:23Z
dc.date.available2017-11-09T05:12:23Z
dc.date.issued2013
dc.description.abstractMuscular dystrophy is a condition potentially predisposing for cancer; however, currently, only Myotonic dystrophy patients are known to have a higher risk of cancer. Here, we have searched for a link between facioscapulohumeral dystrophy (FSHD) and cancer by comparing published transcriptome signatures of FSHD and various malignant tumours and have found a significant enrichment of cancer-related genes among the genes differentially expressed in FSHD. The analysis has shown that gene expression profiles of FSHD myoblasts and myotubes resemble that of Ewing’s sarcoma more than that of other cancer types tested. This is the first study demonstrating a similarity between FSHD and cancer cell expression profiles, a finding that might indicate the existence of a common step in the pathogenesis of these two diseases.ru_RU
dc.identifier.citationDmitriev Petr et al.(>7), 2013, Cancer-related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubes, Journal of Cellular and Molecular Medicine, Vol.18, 208-217ru_RU
dc.identifier.uridoi: 10.1111/jcmm.12182
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/2765
dc.language.isoenru_RU
dc.publisherJournal of Cellular and Molecular Medicineru_RU
dc.rightsOpen Access - the content is available to the general publicru_RU
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectcancerru_RU
dc.subjectrhabdomyosarcomaru_RU
dc.subjectEwing’s sarcomaru_RU
dc.subjectFSHDru_RU
dc.subjectmuscular dystrophyru_RU
dc.titleCancer-related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubesru_RU
dc.typeArticleru_RU

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