ASSESSMENT OF MICROPLASMA SPRAYING OF BIOACTIVE COATINGS ON TITANIUM IMPLANTS FOR BIOCOMPATIBILITY IN VITRO
Loading...
Date
2024-04
Authors
Nwachukwu, China Jesse
Journal Title
Journal ISSN
Volume Title
Publisher
Nazarbayev University School of Engineering and Digital Sciences
Abstract
This study presents an assessment of microplasma spraying (MPS) as a technique for applying
bioactive coatings on titanium implants to enhance biocompatibility in vitro. The research aims to
evaluate the effectiveness of MPS in promoting osteogenic differentiation and antimicrobial activity of
titanium implants through in vitro assays. Surface-modified titanium implants with zirconium,
hydroxyapatite, tantalum, and titanium coatings of varying roughness were fabricated using MPS.
Osteogenic differentiation potential was assessed via alkaline phosphatase (ALP) activity and alizarin
red staining, revealing significant variations in mineralization among the different coatings.
Antimicrobial studies utilizing Escherichia coli as a model organism demonstrated differential growth
kinetics in the presence of implant material extracts, suggesting potential antimicrobial properties
associated with specific coatings. The results underscore the importance of surface modifications in
influencing osteogenic differentiation and antimicrobial activity of titanium implants. Zirconium,
hydroxyapatite, and tantalum coatings exhibited distinct mineralization patterns and antimicrobial
effects compared to uncoated titanium, highlighting the potential of MPS in enhancing the
biocompatibility of titanium implants. These findings contribute to the understanding of surface
engineering techniques for implant materials and pave the way for further research aimed at optimizing
coating formulations and deposition parameters to improve implant performance and clinical outcomes
Description
Keywords
Type of access: Restricted
Citation
Nwachukwu, Ch. J. (2024). Assessment Of Microplasma Spraying Of Bioactive Coatings On Titanium Implants For Biocompatibility In Vitro. Nazarbayev University School of Engineering and Digital Sciences