Astroprotective potential of extract from limonium gmelinii for stroke therapy

Abstract

It's known that proinflammatory cytokines, such asTNF-a, produced by injured neurons and infiltrated leukocytes, involved in every aspect of stroke. Cytokines promote activation of astroglia, induce oxidative stress thereby exacerbating brain tissue damage. There is a number of data indicating that polyphenols can provide protection against neurodegenerative changes. It has been reported previously, that reach with polyphenols extract of Limonium gmelinii exerts a wide range of therapeutic actions. Here, we aimed to study antioxidant and anti-inflammatory potential of L. gmelinii under exposure of TNF-a in vitro.