COMBINED SUPPLEMENTATION OF COENZYME Q10 AND OTHER NUTRIENTS IN SPECIFIC MEDICAL CONDITIONS
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Date
2022
Authors
Tippairote, Torsak
Bjørklund, Geir
Gasmi, Amin
Semenova, Yuliya
Peana, Massimiliano
Chirumbolo, Salvatore
Hangan, Tony
Journal Title
Journal ISSN
Volume Title
Publisher
Nutrients
Abstract
Coenzyme Q10 (CoQ10) is a compound with a crucial role in mitochondrial bioenergetics
and membrane antioxidant protection. Despite the ubiquitous endogenous biosynthesis, specific
medical conditions are associated with low circulating CoQ10 levels. However, previous studies of
oral CoQ10 supplementation yielded inconsistent outcomes. In this article, we reviewed previous
CoQ10 trials, either single or in combination with other nutrients, and stratified the study participants
according to their metabolic statuses and medical conditions. The CoQ10 supplementation trials in
elders reported many favorable outcomes. However, the single intervention was less promising when
the host metabolic statuses were worsening with the likelihood of multiple nutrient insufficiencies,
as in patients with an established diagnosis of metabolic or immune-related disorders. On the
contrary, the mixed CoQ10 supplementation with other interacting nutrients created more promising
impacts in hosts with compromised nutrient reserves. Furthermore, the results of either single or
combined intervention will be less promising in far-advanced conditions with established damage,
such as neurodegenerative disorders or cancers. With the limited high-level evidence studies on
each host metabolic category, we could only conclude that the considerations of whether to take
supplementation varied by the individuals’ metabolic status and their nutrient reserves. Further
studies are warranted.
Description
Keywords
coenzyme Q10, dietary supplements, ubiquinone, mitochondria, bioenergetics, combined supplements
Citation
Tippairote, T., Bjørklund, G., Gasmi, A., Semenova, Y., Peana, M. F., Chirumbolo, S., & Hangan, T. (2022). Combined Supplementation of Coenzyme Q10 and Other Nutrients in Specific Medical Conditions. Nutrients, 14(20), 4383. https://doi.org/10.3390/nu14204383