STAPHYLOCOCCUS AUREUS INFECTION AND PERSISTENCE IN CHRONIC RHINOSINUSITIS: FOCUS ON LEUKOCIDIN ED
Loading...
Date
2020-10-28
Authors
Poddighe, Dimitri
Vangelista, Luca
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
Chronic rhinosinusitis (CRS) is thought to be a multifactorial disease that includes
a direct involvement of bacteria that trigger inflammation and contribute to CRS pathogenesis.
Staphylococcus aureus infection and persistence is associated with chronic rhinosinusitis (CRS),
and it may be particularly relevant in the form with nasal polyps (CRSwNP). The large array of
exotoxins deployed by S. aureus is instrumental for the bacterium to warrant its infection and
dissemination in different human body districts. Here, we analyze the common Th2 environment in
CRSwNP and prospect a possible dynamic role played by S. aureus leukocidins in promoting this
chronic inflammation, considering leukocidin ED (LukED) as a strong prototype candidate worth of
therapeutic investigation. CCR5 is an essential target for LukED to exert its cytotoxicity towards T cells,
macrophages and dendritic cells. Therefore, CCR5 blockade might be an interesting therapeutic option
for CRS and, more specifically, persistent and relapsing CRSwNP. In this perspective, the arsenal of
CCR5 antagonists being developed to inhibit HIV-1 entry (CCR5 being the major HIV-1 co-receptor)
could be easily repurposed for CRS therapeutic investigation. Finally, direct targeting of LukED by
neutralizing antibodies could represent an important additional solution to S. aureus infection.
Description
Keywords
Staphylococcus aureus, chronic rhinosinusitis (CRS), persistent infection, nasal polyps, LukED, CCR5, Research Subject Categories::MEDICINE
Citation
Poddighe, D., & Vangelista, L. (2020). Staphylococcus aureus Infection and Persistence in Chronic Rhinosinusitis: Focus on Leukocidin ED. Toxins, 12(11), 678. https://doi.org/10.3390/toxins12110678