LSP PROJECT REPORT DEVELOPMENT OF HEPG CELL LINE WITH HUMAN NTCP GENE
| dc.contributor.author | Irgaliyev, Abdyrakhman | |
| dc.date.accessioned | 2024-11-27T11:27:01Z | |
| dc.date.available | 2024-11-27T11:27:01Z | |
| dc.date.issued | 2024 | |
| dc.description.abstract | Hepatitis B virus (HBV) is one of the most common viral infections of the liver. There are 296 million people around the world with chronic hepatitis B and 1.5 million new cases emerge each year (WHO on Hepatitis B, 2021). Also, complications of hepatitis B virus such as liver cirrhosis and hepatocellular carcinoma were the cause of 820 000 deaths in 2019. It creates a significant economic and social burden, especially in developing countries. Until the 2010s the proper mechanism of viral internalization of hepatitis B virus was not properly understood. However, discovery of Na+-taurocholate cotransporting polypeptide (NTCP) protein allowed better understanding of the process as well as new possibilities in treatment. Common anti-HBV treatment is usually antiretroviral utilizing its usage of reverse transcriptase. The discovery of a specific viral entry point may allow development of new treatment options. However, expression of NTCP is downregulated in in vitro hepatocytes. This poses an obstacle in creating a testing field for medication options. Sadly, during this research the results were not achieved due to shortage of time and difficulties with competent cells. | |
| dc.identifier.citation | Irgaliyev, A. (2024). LSP project report Development of HepG cell line with human NTCP gene. Nazarbayev University School of Medicine | |
| dc.identifier.uri | https://nur.nu.edu.kz/handle/123456789/8322 | |
| dc.language.iso | en | |
| dc.publisher | Nazarbayev University School of Medicine | |
| dc.rights | Attribution-NonCommercial-ShareAlike 3.0 United States | en |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/us/ | |
| dc.subject | Type of access: | |
| dc.subject | Hepatitis B virus | |
| dc.title | LSP PROJECT REPORT DEVELOPMENT OF HEPG CELL LINE WITH HUMAN NTCP GENE | |
| dc.type | Master`s thesis |
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