The role of the N-terminal domain of human apurinic/apyrimidinic endonuclease 1, APE1, in DNA glycosylase stimulation

dc.contributor.author	Kladova, Olga A.
dc.date.accessioned	2025-08-18T10:59:53Z
dc.date.available	2025-08-18T10:59:53Z
dc.date.issued	2018-04
dc.description.abstract	The N-terminal domain of human APE1 is shown to be essential for stimulating DNA glycosylases (OGG1, MBD4, ANPG). Electron microscopy reveals APE1 oligomerization along DNA with helix distortions that enhance enzyme–substrate interactions and turnover, particularly on short duplexes—suggesting a mechanism that facilitates efficient base excision repair.	en
dc.identifier.citation	Kladova, O.A.; Bazlekowa-Karaban, M.; Baconnais, S.; Piétrement, O.; Ishchenko, A.A.; Matkarimov, B.T.; Iakovlev, D.A.; Vasenko, A.; Fedorova, O.S.; Le Cam, E.; Tudek, B.; Kuznetsov, N.A.; Saparbaev, M. (2018). The role of the N-terminal domain of human apurinic/apyrimidinic endonuclease 1, APE1, in DNA glycosylase stimulation. DNA Repair, 64, 10–25. DOI: 10.1016/j.dnarep.2018.02.001	en
dc.identifier.doi	10.1016/j.dnarep.2018.02.001
dc.identifier.other	Filename:10.1016_j.dnarep.2018.02.001.pdf
dc.identifier.uri	https://doi.org/10.1016/j.dnarep.2018.02.001
dc.identifier.uri	https://nur.nu.edu.kz/handle/123456789/9284
dc.language.iso	en
dc.publisher	Elsevier
dc.relation.ispartof	DNA Repair	en
dc.source	DNA Repair, 64, 10–25, (2018)	en
dc.subject	APE1	en
dc.title	The role of the N-terminal domain of human apurinic/apyrimidinic endonuclease 1, APE1, in DNA glycosylase stimulation	en
dc.type	Journal Article	en

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