Development of technology and study of optimized secreted products of stem cells for collaterogenesis

Abstract

Cell therapy using stem cells is a promising strategy for the treatment of ischemic diseases, nevertheless low viability of implanted cells, is one of the main problems limiting stem cell therapy. In addition, there is a risk of proliferation of the transformed cells in mesenchymal stem cells carrying properties of cancer stem cells. Using conditioned media from stem cells instead of stem cell themselves avoids the risks that may arise with the direct use of stem cells. Conditioned media from various stem cells contains a different number of cytokines and growth factors, necessary for the natural process of new vessel formation.