COMPUTATIONAL FLUID DYNAMICS IN PANCREATICOBILIARY JUNCTION
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Date
2024-04
Authors
Turgaliyev, Alim
Journal Title
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Publisher
Nazarbayev University School of Engineering and Digital Sciences
Abstract
Pancreaticobiliary maljunction without biliary dilation is associated with
pancreaticobiliary reflux, a pathophysiologic factor underlying a wide range of diseases,
including gallbladder cancer. This work used computational flow simulations to examine the
mechanisms and relevant geometric features that influence pancreaticobiliary reflux and
assess the impact of surgical interventions.
The results suggest that the refilling phase is the primary mechanism driving
pancreaticobiliary reflux. Moreover, the cystic duct diameter was the most critical factor
determining the reflux dynamics. Furthermore, the configuration of the baffle system (the
baffle height ratio and the number of baffles) affected the dynamics of pancreaticobiliary
reflux.
Also, the study underscores the potential therapeutic efficacy of cholecystectomy and
endoscopic retrograde cholangiopancreatography in managing pancreaticobiliary reflux in
cases of pancreaticobiliary maljunction without biliary dilatation. These interventions offer
promising avenues for reducing reflux-related complications and mitigating the progression of
associated diseases.
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Type of access: Embargo
Citation
Turgaliyev, A. (2024). Computational Fluid Dynamics In Pancreaticobiliary Junction. Nazarbayev University School of Engineering and Digital Sciences