Impacts of membrane biophysics in Alzheimer’s disease: from amyloid precursor protein processing to Aβ peptide-induced membrane changes

Simple item page
dc.contributor.authorAskarova, Sholpan
dc.contributor.authorYang, Xiaoguang
dc.contributor.authorLee, James C-M.
dc.date.accessioned2016-02-08T06:11:00Z
dc.date.available2016-02-08T06:11:00Z
dc.date.issued2011-01-21
dc.description.abstractAn increasing amount of evidence supports the notion that cytotoxic effects of amyloid-β peptide (Aβ), the main constituent of senile plaques in Alzheimer’s disease (AD), are strongly associated with its ability to interact with membranes of neurons and other cerebral cells. Aβ is derived from amyloidogenic cleavage of amyloid precursor protein (AβPP) by β- and γ-secretase. In the nonamyloidogenic pathway, AβPP is cleaved by α-secretases. These two pathways compete with each other, and enhancing the non-amyloidogenic pathway has been suggested as a potential pharmacological approach for the treatment of AD. Since AβPP, α-, β-, and γ-secretases are membrane-associated proteins, AβPP processing and Aβ production can be affected by the membrane composition and properties. There is evidence that membrane composition and properties, in turn, play a critical role in Aβ cytotoxicity associated with its conformational changes and aggregation into oligomers and fibrils. Understanding themechanisms leading to changes in a membrane’s biophysical properties and how they affect AβPP processing and Aβ toxicity should prove to provide new therapeutic strategies for prevention and treatment of AD.ru_RU
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/1175
dc.language.isoenru_RU
dc.publisherSAGE-Hindawi Access to Research International Journal of Alzheimer’s Diseaseru_RU
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectResearch Subject Categories::TECHNOLOGY::Bioengineeringru_RU
dc.subjectregenerative medicineru_RU
dc.subjectResearch Subject Categories::MEDICINE::Physiology and pharmacology::Physiology::Neurophysiologyru_RU
dc.titleImpacts of membrane biophysics in Alzheimer’s disease: from amyloid precursor protein processing to Aβ peptide-induced membrane changesru_RU
dc.typeArticleru_RU

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Impacts ofMembrane.pdf
Size:
1.27 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
6.22 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Research Institute of Bioengineering, Regenerative Medicine and Neurophysiology