THE DOSE-DEPENDENT EFFECT OF ANTI-MICROTUBULE DRUGS ON CANCER CELLS

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dc.contributor.authorBekbayev, Sultan
dc.date.accessioned2021-05-12T08:58:25Z
dc.date.available2021-05-12T08:58:25Z
dc.date.issued2021-05-08
dc.description.abstractDrugs inhibiting microtubule dynamics are widely used in the treatment of various types of cancer. However, the molecular mechanisms are not fully investigated. The aim of this thesis is to study drug- and dose-dependent effect of the inhibitors of microtubule drugs on the cancer cells by treating them with the wide range of concentrations anti-microtubule drugs and observing the fate of mitotic cells directly under microscope. This will allow us to obtain systematic knowledge on the threshold concentrations of anti-microtubule drugs, which will open new prospects in disentangling molecular mechanisms of the action of these drugs. In this work two distinct effects of anti-microtubule drugs were investigated, and they were quantified with introducing the concept of minimal mitostatic concentration, and novel second threshold concentration.en_US
dc.identifier.citationBekbayev, S. (2021). The dose-dependent effect of anti-microtubule drugs on cancer cells (Unpublished mater`s thesis). Nazarbayev University, Nur-Sultan, Kazakhstanen_US
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/5387
dc.language.isoenen_US
dc.publisherNazarbayev University School of Sciences and Humanitiesen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectcanceren_US
dc.subjectcancer cellsen_US
dc.subjectType of access: Open Accessen_US
dc.subjectdrugs inhibiting microtubule dynamicsen_US
dc.subjectminimal mitostatic concentrationen_US
dc.titleTHE DOSE-DEPENDENT EFFECT OF ANTI-MICROTUBULE DRUGS ON CANCER CELLSen_US
dc.typeMaster's thesisen_US
workflow.import.sourcescience

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