Hyperbaric oxygenation and glucose/amino acids substitution in human severe placental insufficiency

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dc.contributor.authorTchirikov, Michael
dc.contributor.authorSaling, Erich
dc.contributor.authorBapayeva, Gauri
dc.contributor.authorBucher, Michael
dc.contributor.authorThews, Oliver
dc.contributor.authorSeliger, Gregor
dc.date.accessioned2020-05-20T06:00:56Z
dc.date.available2020-05-20T06:00:56Z
dc.date.issued2018-03-13
dc.description.abstractIn the first case, the AA and glucose were infused through a perinatal port system into the umbilical vein at 30 weeks' gestation due to severe IUGR. The patient received daily hyperbaric oxygenation (HBO, 100% O2) with 1.4 atmospheres absolute for 50 min for 7 days. At 31+4 weeks' gestation, the patient gave birth spontaneously to a newborn weighing 1378 g, pH 7.33, APGAR score 4/6/intubation. In follow‐up examinations at 5 years of age, the boy was doing well without any neurological disturbance or developmental delay. In the second case, the patient presented at 25/5 weeks' gestation suffering from severe IUGR received HBO and maternal AA infusions. The cardiotocography was monitored continuously during HBO treatment. The short‐time variations improved during HBO from 2.9 to 9 msec. The patient developed pathologic CTG and uterine contractions 1 day later and gave birth to a hypotrophic newborn weighing 420 g. After initial adequate stabilization, the extremely preterm newborn unfortunately died 6 days later. Fetal nutrition combined with HBO is technically possible and may allow the prolongation of the pregnancy. Fetal‐specific amino‐acid composition would facilitate the treatment options of IUGR fetuses and extremely preterm newborn.en_US
dc.identifier.citationTchirikov, M., Saling, E., Bapayeva, G., Bucher, M., Thews, O., & Seliger, G. (2018). Hyperbaric oxygenation and glucose/amino acids substitution in human severe placental insufficiency. Physiological Reports, 6(5), e13589. https://doi.org/10.14814/phy2.13589en_US
dc.identifier.issn2051-817X
dc.identifier.other10.14814/phy2.13589
dc.identifier.urihttps://doi.org/10.14814/phy2.13589
dc.identifier.urihttps://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.13589
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/4747
dc.language.isoenen_US
dc.publisherWiley Open Accessen_US
dc.relation.ispartofseriesPhysiological Reports;
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectAmino acidsen_US
dc.subjectcordocentesisen_US
dc.subjectfetal growthrestrictionen_US
dc.subjectHBOen_US
dc.subjecthyperbaric oxygenationen_US
dc.subjectintrauterine treatmenten_US
dc.subjectintravenous infusionen_US
dc.subjectIUGRen_US
dc.subjectplacental insufficiencyen_US
dc.subjectportimplantationen_US
dc.titleHyperbaric oxygenation and glucose/amino acids substitution in human severe placental insufficiencyen_US
dc.typeArticleen_US
workflow.import.sourcescience

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