INFANTILE GIANT CELL HEPATITIS WITH AUTOIMMUNE HEMOLYTIC ANEMIA

dc.contributor.authorPoddighe, Dimitri
dc.contributor.authorMadiyeva, Aidana
dc.contributor.authorTalipova, Diana
dc.contributor.authorUmirbekova, Balzhan
dc.date.accessioned2021-09-20T08:52:11Z
dc.date.available2021-09-20T08:52:11Z
dc.date.issued2021-04-27
dc.description.abstractGiant cell hepatitis (GCH) is characterized by large and multinucleated (syncytial) hepatocytes in the context of liver inflammation. Infantile GCH is typically associated with autoimmune hemolytic anemia in the absence of any other systemic or organ-specific autoimmune comorbidity. The etiology is unknown; concomitant viral infections (as potential trigger factors) have been identified in a few patients. The pathogenesis reportedly relies upon immune-mediated/ autoimmune mechanisms. This condition should be considered in any infant developing Coombs-positive anemia; indeed, anemia usually precedes the development of hepatitis. The clinical course is usually aggressive without the appropriate immunosuppressive therapy, which may include steroids, conventional immunosuppressors (e.g., azathioprine and cyclophosphamide as first-line treatments), intravenous immunoglobulin, and biologics (rituximab). Improvements in medical management (including the availability of rituximab) have significantly reduced the mortality of this condition in the last decade.en_US
dc.identifier.citationPoddighe, D., Madiyeva, A., Talipova, D., & Umirbekova, B. (2021). Infantile giant cell hepatitis with autoimmune hemolytic anemia. World Journal of Hepatology, 13(4), 411–420. https://doi.org/10.4254/wjh.v13.i4.411en_US
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/5833
dc.language.isoenen_US
dc.publisherWorld Journal of Hepatologyen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectType of access: Open Accessen_US
dc.subjectGiant cell hepatitisen_US
dc.subjectAutoimmune hemolytic anemiaen_US
dc.subjectRituximaben_US
dc.subjectInfantile hepatitisen_US
dc.subjectJaundiceen_US
dc.titleINFANTILE GIANT CELL HEPATITIS WITH AUTOIMMUNE HEMOLYTIC ANEMIAen_US
dc.typeArticleen_US
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