Reflector-less nanoparticles doped optical fiber biosensor for the detection of proteins: Case thrombin

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dc.contributor.authorM. Sypabekova
dc.contributor.authorA. Aitkulov
dc.contributor.authorW. Blanc
dc.contributor.authorD. Tosi
dc.date.accessioned2025-08-20T04:04:43Z
dc.date.available2025-08-20T04:04:43Z
dc.date.issued2020-01-01
dc.description.abstractA miniature biosensing platform based on MgO-based nanoparticle-doped optical fiber was developed for biomolecule detection. A single‑mode fiber with MgO-doped core was etched 1–2 mm from the tip, and Rayleigh backscattering signatures were analyzed. A thin gold layer increased sensitivity by 3.7×. The sensor showed sensitivity of 0.75–19.63 nm per refractive index unit over 1.3329–1.37649 RI, and detected thrombin concentrations from 0.625 μg/mL to 20 μg/mL using thiol‑modified DNA aptamers, demonstrating specificity, multiplexing potential, biocompatibility, and suitability for in vivo use., en
dc.identifier.citationSypabekova, M.; Aitkulov, A.; Blanc, W.; Tosi, D. (2020). Biosens. Bioelectron., 165:112365.en
dc.identifier.urihttps://nur.nu.edu.kz/handle/123456789/9658
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofBiosensors and Bioelectronicsen
dc.rightsAll rights reserveden
dc.sourceBiosensors and Bioelectronics, 165, 112365, (2020)en
dc.subjectoptical fiber biosensoren
dc.subjectnanoparticlesen
dc.subjectthrombin detectionen
dc.subjectlabel-freeen
dc.titleReflector-less nanoparticles doped optical fiber biosensor for the detection of proteins: Case thrombinen
dc.typeJournal Articleen

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