Advances in Computational Immunology

Abstract

In the paper contributed by C.-M. Svensson et al., the authors investigate the interobserver variability of image data comprising fluorescently stained circulating tumor cells and its effect on the performance of two automated classifiers, a random forest and a support vector machine. They found that uncertainty in annotation between observers limited the performance of the automated classifiers, especially when it was included in the test set on which classifier performance was measured.