ACTIVATED CARBON/PECTIN COMPOSITE ENTEROSORBENT FOR HUMAN PROTECTION FROM INTOXICATION WITH XENOBIOTICS PB(II) AND SODIUM DICLOFENAC
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Date
2022
Authors
Jandosov, Jakpar
Alavijeh, Mo
Sultakhan, Shynggyskhan
Baimenov, Alzhan
Bernardo, Maria
Sakipova, Zuriyadda
Azat, Seytkhan
Lyubchyk, Svitlana
Zhylybayeva, Nurzhamal
Naurzbayeva, Gulmira
Journal Title
Journal ISSN
Volume Title
Publisher
Molecules
Abstract
The use of enterosorbents—materials which can be administered orally and eliminate toxic
substances from the gastrointestinal tract (GIT) by sorption—offers an attractive complementary
protection of humans against acute and chronic poisoning. In this study, we report the results of
developing a microgranulated binary biomedical preparation for oral use. It was designed with a
core-shell structure based on pectin with low degree of esterification as the core, and nanoporous
activated carbon produced from rice husk, AC-RH, as the shell, designated as AC-RH@pectin. The
adsorption properties of the synthesized materials were studied in aqueous solutions for the removal
of lead (II) nitrate as a representative of toxic polyvalent metals and sodium diclofenac as an example
of a medicinal drug. The composite enterosorbent demonstrated high adsorption capacity for both
adsorbates studied. Adsorption kinetics of lead and diclofenac adsorption by AC-RH, pectin, and
AC-RH@pectin, fitted well a pseudo-second-order model. According to the Langmuir adsorption
isotherm model, the best fitted isotherm model, the maximum adsorption capacity, qmax, of AC RH@pectin for diclofenac and for lead (II) was 130.9 mg/g and 227.8 mg/g, respectively. Although
qmax of AC-RH for diclofenac, 537.6 mg/g, and qmax of pectin for lead (II), 245.7 mg/g, were higher,
the maximum adsorption capacity of AC-RH for lead (II), 52.7 mg/g, was much lower than that of
the composite AC-RH@pectin and the adsorption capacity of pectin for diclofenac was negligible.
Therefore, the composite material AC-RH@pectin demonstrated substantial efficiency of removing
both species which potentially defines it as a more universal enterosorbent suitable for treating
poisoning caused by substances of different chemical nature.
Description
Keywords
Type of access: Open Access, diclofenac adsorption, lead adsorption, enterosorbent, pectin, porous carbon
Citation
Jandosov, J., Alavijeh, M., Sultakhan, S., Baimenov, A., Bernardo, M., Sakipova, Z., Azat, S., Lyubchyk, S., Zhylybayeva, N., Naurzbayeva, G., Mansurov, Z., Mikhalovsky, S., & Berillo, D. (2022). Activated Carbon/Pectin Composite Enterosorbent for Human Protection from Intoxication with Xenobiotics Pb(II) and Sodium Diclofenac. Molecules, 27(7), 2296. https://doi.org/10.3390/molecules27072296