A NEW INSIGHT ON THE RADIOPROTECTIVE POTENTIAL OF EPSILON-AMINOCAPROIC ACID
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Date
2020-11-25
Authors
Takagi, Satoshi
Oyama, Takuto
Jimi, Shiro
Saparov, Arman
Ohjimi, Hiroyuki
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
Negative pressure wound therapy (NPWT) has been commonly used over the years for
a wide range of chronic/refractory lesions. Alternatively, autologous micrografting technology is
recently becoming a powerful modality for initiating wound healing. The case presented is of a patient
with a lower leg ulcer that had responded poorly to NPWT alone for three weeks. Consequently,
the patient was put on a combination therapy of NPWT and micrografting. After injection of a dermal
tissue micrografts suspension into the entire wound bed, NPWT was performed successively for
two weeks, resulting in fresh granulation tissue formation. Thereafter, the autologous skin graft was
taken well. This case study indicates that for a chronic/refractory ulcer patient with poor NPWT
outcome, combination therapy using micrografting treatment and NPWT could rapidly initiate and
enhance granulation tissue formation, creating a favorable bedding for subsequent skin grafting.
Description
Keywords
regenerative medicine, chronic wounds, micrografts, Research Subject Categories::MEDICINE
Citation
Saliev, T., Baiskhanova, D., Beznosko, D., Begimbetova, D., Umbayev, B., Nurgozhin, T., Fakhradiyev, I., Tanabayev, B., & Pavalkis, D. (2020). A New Insight on the Radioprotective Potential of Epsilon-Aminocaproic Acid. Medicina, 56(12), 663. https://doi.org/10.3390/medicina56120663