EFFECT OF INHIBITION OF ANTI-APOPTOTIC BCL-2 PROTEINS ON THE OUTCOME OF MITOTIC ARREST INDUCED BY MICROTUBULE TARGETING DRUGS

Abstract

Anti-mitotic drugs induce prolonged mitotic arrest followed either by death in mitosis (DiM) or by mitotic slippage (Rieder and Maiato, 2004). The model explaining DiM versus mitotic slippage proposed by Gascoigne and Taylor in 2008 states about the two competing networks between well-documented cyclin B1 degradation and undefined pro-death signal (Brito and Rieder, 2006; Terrano et.al, 2010). The major purpose of this work is to study the nature and regulation of the mechanism of cell death after treatment with MT drugs.