CASE REPORT: ATYPICAL TERATOID/RHABDOID TUMOR OF THE LATERAL VENTRICLE IN A MALE ADOLESCENT (CASE-BASED REVIEW AND DIAGNOSTIC CHALLENGES IN DEVELOPING COUNTRIES)
| dc.contributor.author | Karim, Akzhol | |
| dc.contributor.author | Shaikhyzada, Kundyz | |
| dc.contributor.author | Suleimenova, Assel | |
| dc.contributor.author | Ibraimov, Bakytkali | |
| dc.contributor.author | Nurgaliev, Dair | |
| dc.contributor.author | Poddighe, Dimitri | |
| dc.date.accessioned | 2022-12-01T10:02:05Z | |
| dc.date.available | 2022-12-01T10:02:05Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Atypical teratoid/rhabdoid tumor (AT/RT) is a rare and highly malignant central nervous system (CNS) embryonal neoplasm: it accounts for <2% of all pediatric CNS tumors and occurs mainly in infants and young children. The primary site of this tumor is usually the posterior cranial fossa. Supratentorial and, in detail, latero-ventricular location is extremely uncommon, especially in adolescents. This tumor is characterized by rapid growth and spread in cerebrospinal fluid and, therefore, it is characterized by a poor prognosis. Neurological signs and symptoms are related the location of the tumor. The radiological features of AT/RT are nonspecific. Immunohistochemical staining for loss of nuclear integrase interactor 1 (INI1) expression is considered a reliable criterion for the diagnosis of this type of tumor. AT/RT has been linked to mutations of SMARCB1 or, rarely, SMARCA4 genes, which function as tumor suppressor genes. Currently, there is no validated protocol of treatment for children with AT/RT, and multimodality treatment (consisting of surgery, chemotherapy, and radiation therapy) is considered. In this case report, we describe a 15-year-old adolescent with an AT/RT of the left lateral ventricle. Despite the late diagnosis, the multimodal therapeutic approach provided a good outcome for our patient at 21 months' follow-up. Based on our case-based review, early diagnosis and a multimodal approach to treatment play a key role in improving the survival of patients with this diagnosis. Implementing a system supporting pathological and molecular analyses for developing countries and, in general, for non-academic centers is of primary importance to timely diagnose and treat rare tumors, such as AT/RT. | en_US |
| dc.identifier.citation | Karim, A., Shaikhyzada, K., Suleimenova, A., Ibraimov, B., Nurgaliev, D., & Poddighe, D. (2022). Case report: Atypical teratoid/rhabdoid tumor of the lateral ventricle in a male adolescent (case-based review and diagnostic challenges in developing countries). Frontiers in Oncology, 12. https://doi.org/10.3389/fonc.2022.985862 | en_US |
| dc.identifier.uri | http://nur.nu.edu.kz/handle/123456789/6851 | |
| dc.language.iso | en | en_US |
| dc.publisher | Frontiers in Oncology | en_US |
| dc.rights | Attribution-NonCommercial-ShareAlike 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/us/ | * |
| dc.subject | Type of access: Open Access | en_US |
| dc.subject | adolescent | en_US |
| dc.subject | atypical teratoid/rhabdoid tumor | en_US |
| dc.subject | case report | en_US |
| dc.subject | case-based review | en_US |
| dc.subject | lateral ventricle | en_US |
| dc.subject | pediatric brain tumor | en_US |
| dc.title | CASE REPORT: ATYPICAL TERATOID/RHABDOID TUMOR OF THE LATERAL VENTRICLE IN A MALE ADOLESCENT (CASE-BASED REVIEW AND DIAGNOSTIC CHALLENGES IN DEVELOPING COUNTRIES) | en_US |
| dc.type | Article | en_US |
| workflow.import.source | science |