DOES COVID-19 CONTRIBUTE TO DEVELOPMENTOF NEUROLOGICAL DISEASE?

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dc.contributor.authorMahalakshmi, Arehally M.
dc.contributor.authorRay, Bipul
dc.contributor.authorTuladhar, Sunanda
dc.contributor.authorBhat, Abid
dc.contributor.authorPaneyala, Shasthara
dc.contributor.authorPatteswari, Duraisamy
dc.contributor.authorSakharkar, Meena Kishore
dc.contributor.authorHamdan, Hamdan
dc.contributor.authorOjcius, David M.
dc.contributor.authorBolla, Srinivasa Rao
dc.contributor.authorEssa, Musthafa Mohamed
dc.contributor.authorChidambaram, Saravana Babu
dc.contributor.authorQoronfleh, M. Walid
dc.date.accessioned2021-01-25T06:30:22Z
dc.date.available2021-01-25T06:30:22Z
dc.date.issued2020-12-17
dc.description.abstractBackground Although coronavirus disease 2019 (COVID‐19) has been associated primarily with pneumonia, recent data show that the causative agent of COVID‐19, the coronavirus severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), can infect a large number of vital organs beyond the lungs, such as the heart, kidneys, and the brain. Thus, there is evidence showing possible retrograde transmission of the virus from the olfactory epithelium to regions of the brain stem. Methods This is a literature review article. The research design method is an evidence‐based rapid review. The present discourse aim is first to scrutinize and assess the available literature on COVID‐19 repercussion on the central nervous system (CNS). Standard literature and database searches were implemented, gathered relevant material, and extracted information was then assessed. Results The angiotensin‐converting enzyme 2 (ACE2) receptors being the receptor for the virus, the threat to the central nervous system is expected. Neurons and glial cells express ACE2 receptors in the CNS, and recent studies suggest that activated glial cells contribute to neuroinflammation and the devastating effects of SARS‐CoV‐2 infection on the CNS. The SARS‐CoV‐2‐induced immune‐mediated demyelinating disease, cerebrovascular damage, neurodegeneration, and depression are some of the neurological complications discussed here. Conclusion This review correlates present clinical manifestations of COVID‐19 patients with possible neurological consequences in the future, thus preparing healthcare providers for possible future consequences of COVID‐19.en_US
dc.identifier.citationMahalakshmi, A. M., Ray, B., Tuladhar, S., Bhat, A., Paneyala, S., Patteswari, D., Sakharkar, M. K., Hamdan, H., Ojcius, D. M., Bolla, S. R., Essa, M. M., Chidambaram, S. B., & Qoronfleh, M. W. (2020). Does COVID‐19 contribute to development of neurological disease? Immunity, Inflammation and Disease. https://doi.org/10.1002/iid3.387en_US
dc.identifier.issn2050-4527
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/iid3.387
dc.identifier.urihttps://doi.org/10.1002/iid3.387
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/5235
dc.language.isoenen_US
dc.publisherWiley Open Accessen_US
dc.relation.ispartofseriesImmunity, Inflammation and Disease;2020; 1–11
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectACE2en_US
dc.subjectCOVID-19en_US
dc.subjectglial cellsen_US
dc.subjectimmune mediated demyelinationen_US
dc.subjectmemory impairmenten_US
dc.subjectneurodegenerationen_US
dc.subjectneuroinflammationen_US
dc.subjectneurological circuitsen_US
dc.subjectneurologyen_US
dc.subjectSARS-CoV-2en_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleDOES COVID-19 CONTRIBUTE TO DEVELOPMENTOF NEUROLOGICAL DISEASE?en_US
dc.typeArticleen_US
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