Development of a recombinant foot -and-mouth disease vaccine

Abstract

Foot-and-mouth disease (FMD) is important disease of cloven-foot animals including cows and swine. Although annual vaccination against the FMD is mandated in regions of South Kazakhstan, outbreaks of the disease are registered every year. These outbreaks result in huge economic losses because international rules require culling of all the diseased and contacted animals and all products from these animals must be destroyed. Currently available anti-FMD vaccines are all produced using the original technology of inactivation of virus (foot-and-mouth disease virus, FMDV) grown in cell cultures. Recombinant anti-FMD vaccine is a long anticipated development in the industry because the recombinant vaccine is safe and compatible with diagnostic tests for discrimination of diseased and vaccinated animals (DIVA).