Gold-catalyzed post-Ugi alkyne hydroarylation for the synthesis of 2-quinolones

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dc.contributor.authorXiaochen Du
dc.contributor.authorJianjun Huang
dc.contributor.authorAnton A. Nechaev
dc.contributor.authorRuwei Yao
dc.contributor.authorJing Gong
dc.contributor.authorErik V. Van der Eycken
dc.contributor.authorOlga P. Pereshivko
dc.contributor.authorVsevolod A. Peshkov
dc.date.accessioned2025-08-06T10:43:31Z
dc.date.available2025-08-06T10:43:31Z
dc.date.issued2018
dc.description.abstractA series of propargylamides containing an electron-rich benzene ring was prepared via a Ugi four-component condensation. These adducts underwent gold-catalyzed intramolecular alkyne hydroarylation to efficiently construct the 2-quinolone core with N‑branched substituents. The method demonstrated broad substrate scope, high yields (up to 97 %), and favorable environmental profile using fluorinated alcohols as solvents.
dc.identifier.citationDu, X.; Huang, J.; Nechaev, A. A.; Yao, R.; Gong, J.; Van der Eycken, E. V.; Pereshivko, O. P.; Peshkov, V. A. (2018). Gold-catalyzed post-Ugi alkyne hydroarylation for the synthesis of 2-quinolones. Beilstein Journal of Organic Chemistry, 14, 2572–2579. DOI: 10.3762/bjoc.14.234
dc.identifier.urihttps://nur.nu.edu.kz/handle/123456789/9101
dc.language.isoen
dc.subjectgold catalysis
dc.subjecthydroarylation
dc.subject2-quinolones
dc.subjectUgi reaction
dc.titleGold-catalyzed post-Ugi alkyne hydroarylation for the synthesis of 2-quinolones
dc.typeArticle

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