A toxicological and genotoxicological indexing study of ambient aerosols (PM2.5-10) using in vitro bioassays

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dc.contributor.authorAammi, Saida
dc.contributor.authorKaraca, Ferhat
dc.contributor.authorPetek, Mustafa
dc.creatorSaida, Aammi
dc.date.accessioned2017-12-20T10:00:48Z
dc.date.available2017-12-20T10:00:48Z
dc.date.issued2017-05-01
dc.description.abstractAbstract This study evaluates the toxicity and genotoxicity levels of atmospheric particulate matter (PM) samples collected at several locations of a megacity (Istanbul, Turkey) with different urban and industrial characteristics. The ambient air samples, in the form of a coarse fraction of inhalable particulates, PM2.5-10, were collected on Teflon filters using a passive sampling method on a monthly basis during a one-year period. Later, they were extracted into both the lipophilic and hydrophilic phases using dimethyl sulfoxide (DMSO) and ultra-pure water, respectively. The obtained aqueous extracts were tested for acute toxicity and genotoxicity using the photo-luminescent bacterium Vibrio fischeri Microtox® and SOS Chromotest® assays, respectively. Statistically significant differences greater than background levels were obtained in both measurements, indicating the presence of toxic substances absorbed on particulate matter. The PM2.5-10 extracts identified significant seasonal and locational differences in the toxicity and genotoxicity levels. Local anthropogenic activities and factors were associated with the quantified higher levels. Finally, a qualitative inner comparison study of regional toxicity and genotoxicity indexes was suggested to provide a clearer picture of the pollution and risk levels (or occurrences) in the Istanbul urban area. In this indexing study, the threshold levels for the urban background and episodic occurrences of the toxicity and genotoxicity levels in PM2.5-10 samples were identified to be 1.11 TU (Toxicity Unit) and 8.73 TU and 0.72 IF (Induction Factor) and 1.38 IF, respectively.en_US
dc.identifierDOI:10.1016/j.chemosphere.2017.01.141
dc.identifier.citationSaida Aammi, Ferhat Karaca, Mustafa Petek, A toxicological and genotoxicological indexing study of ambient aerosols (PM2.5-10) using in vitro bioassays, In Chemosphere, Volume 174, 2017, Pages 490-498en_US
dc.identifier.issn00456535
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0045653517301571
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/2975
dc.language.isoenen_US
dc.publisherChemosphereen_US
dc.relation.ispartofChemosphere
dc.rights.license© 2017 Elsevier Ltd. All rights reserved.
dc.subjectPM10en_US
dc.subjectAir quality monitoringen_US
dc.subjectToxicityen_US
dc.subjectGenotoxicityen_US
dc.subjectMicrotoxen_US
dc.subjectVibrio fischerien_US
dc.subjectSOS Chromotesten_US
dc.titleA toxicological and genotoxicological indexing study of ambient aerosols (PM2.5-10) using in vitro bioassaysen_US
dc.typeArticleen_US
elsevier.aggregationtypeJournal
elsevier.coverdate2017-05-01
elsevier.coverdisplaydateMay 2017
elsevier.endingpage498
elsevier.identifier.doi10.1016/j.chemosphere.2017.01.141
elsevier.identifier.eid1-s2.0-S0045653517301571
elsevier.identifier.piiS0045-6535(17)30157-1
elsevier.identifier.pubmedid28189894
elsevier.identifier.scopusid85011796786
elsevier.openaccess0
elsevier.openaccessarticlefalse
elsevier.openarchivearticlefalse
elsevier.startingpage490
elsevier.teaserThis study evaluates the toxicity and genotoxicity levels of atmospheric particulate matter (PM) samples collected at several locations of a megacity (Istanbul, Turkey) with different urban and industrial...
elsevier.volume174
workflow.import.sourcescience

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