IN SITU TRANSFORMATION OF ELECTROSPUN NANOFIBERS INTO NANOFIBER-REINFORCED HYDROGELS
| dc.contributor.author | Martin, Alma | |
| dc.contributor.author | Nyman, Jenny Natalie | |
| dc.contributor.author | Reinholdt, Rikke | |
| dc.contributor.author | Cai, Jun | |
| dc.contributor.author | Schaedel, Anna-Lena | |
| dc.contributor.author | J. A. van der Plas, Mariena | |
| dc.contributor.author | Malmsten, Martin | |
| dc.contributor.author | Rades, Thomas | |
| dc.contributor.author | Heinz, Andrea | |
| dc.date.accessioned | 2023-06-27T10:15:42Z | |
| dc.date.available | 2023-06-27T10:15:42Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Nanofiber-reinforced hydrogels have recently gained attention in biomedical engineering. Such three-dimensional scaffolds show the mechanical strength and toughness of fibers while benefiting from the cooling and absorbing properties of hydrogels as well as a large pore size, potentially aiding cell migration. While many of such systems are prepared by complicated processes where fibers are produced separately to later be embedded in a hydrogel, we here provide proof of concept for a one-step solution. In more detail, we produced core-shell nanofibers from the natural proteins zein and gelatin by coaxial electrospinning. Upon hydration, the nanofibers were capable of directly transforming into a nanofiber-reinforced hydrogel, where the nanofibrous structure was retained by the zein core, while the gelatin-based shell turned into a hydrogel matrix. Our nanofiber-hydrogel composite showed swelling to ~800% of its original volume and water uptake of up to ~2500% in weight. The physical integrity of the nanofiber-reinforced hydrogel was found to be significantly improved in comparison to a hydrogel system without nanofibers. Additionally, tetracycline hydrochloride was incorporated into the fibers as an antimicrobial agent, and antimicrobial activity against Staphylococcus aureus and Escherichia coli was confirmed. | en_US |
| dc.identifier.citation | Martin, A., Nyman, J. N., Reinholdt, R., Cai, J., Schaedel, A., Van Der Plas, M. J. A., Malmsten, M., Rades, T., & Heinz, A. (2022). In Situ Transformation of Electrospun Nanofibers into Nanofiber-Reinforced Hydrogels. Nanomaterials, 12(14), 2437. https://doi.org/10.3390/nano12142437 | en_US |
| dc.identifier.uri | http://nur.nu.edu.kz/handle/123456789/7269 | |
| dc.language.iso | en | en_US |
| dc.publisher | Nanomaterials | en_US |
| dc.rights | Attribution-NonCommercial-ShareAlike 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/us/ | * |
| dc.subject | Type of access: Open Access | en_US |
| dc.subject | biomaterial | en_US |
| dc.subject | coaxial electrospinning | en_US |
| dc.subject | composite material | en_US |
| dc.subject | mechanical properties | en_US |
| dc.subject | tissue engineering | en_US |
| dc.subject | wound healing | en_US |
| dc.title | IN SITU TRANSFORMATION OF ELECTROSPUN NANOFIBERS INTO NANOFIBER-REINFORCED HYDROGELS | en_US |
| dc.type | Article | en_US |
| workflow.import.source | science |