Pathogen-driven gastrointestinal cancers: Time for a change in treatment paradigm?

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dc.contributor.authorAituov, Bauyrzhan
dc.contributor.authorDuisembekova, Assem
dc.contributor.authorBulenova, Assel
dc.contributor.authorAlibek, Kenneth
dc.date.accessioned2017-11-08T04:43:59Z
dc.date.available2017-11-08T04:43:59Z
dc.date.issued2012
dc.description.abstractThe regulation of cancerous tumor development is converged upon by multiple pathways and factors. Besides environmental factors, gastrointestinal (GI) tract cancer can be caused by chronic inflammation, which is generally induced by bacteria, viruses, and parasites. The role of these inducers in cancer development, cell differentiation and transformation, cell cycle deregulation, and in the expression of tumor-associated genes cannot be ignored. Although Helicobacter pylori activates many oncogenic pathways, particularly those in gastric and colorectal cancers, the role of viruses in tumor development is also significant. Viruses possess significant oncogenic potential to interfere with normal cell cycle control and genome stability, stimulating the growth of deregulated cells. An increasing amount of recent data also implies the association of GI cancers with bacterial colonization and viruses.This review focuses on host-cell interactions that facilitate primary mechanisms of tumorigenesis and provides new insights into novel GI cancer treatments.ru_RU
dc.identifier.citationAituov et al.(>3), 2012, Pathogen-driven gastrointestinal cancers: Time for a change in treatment paradigm?,Infectious Agents and Cancerru_RU
dc.identifier.issn1750-9378
dc.identifier.uridoi:10.1186/1750-9378-7-18
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/2748
dc.language.isoenru_RU
dc.publisherInfectious Agents and Cancerru_RU
dc.rightsOpen Access - the content is available to the general publicru_RU
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectgastric cancerru_RU
dc.subjectColorectal cancerru_RU
dc.subjectLiver cancerru_RU
dc.subjectHelicobacter pyloriru_RU
dc.subjectCytomegalovirusru_RU
dc.subjectEpstein-Barr virusru_RU
dc.subjectJohn Cunningham virusru_RU
dc.subjectStreptococcus bovisru_RU
dc.subjectHepatitis C virusru_RU
dc.subjectHelminthesru_RU
dc.titlePathogen-driven gastrointestinal cancers: Time for a change in treatment paradigm?ru_RU
dc.typeArticleru_RU

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