SNX 9 interacts with dynamin 2 and N-wasp to regulate focal adhesion disassembly and cell migration

Abstract

The turnover of focal adhesions is essential for normal cell migration and tumor invasion, but the underlying mechanisms are poorly understood. We have previously shown that the disassembly of focal adhesions occurs by endocytosis of activated integrins from adhesion sites (1). We have further identified new components that mediate integrin endocytosis. Here, we provide the initial characterization of one of these components, sorting nexin 9 (Snx9), an endocytic adaptor protein not previously implicated in cell adhesion and migration.